On 14 Jul 1755 James married Anna Bradley (26421) , daughter of Nathaniel Bradley (10438) (16 May 1701-19 Mar 1745/6) & Anna Osborn (48131) (6 Jan 1708/9-), in Second Congregational Society, New Haven.56,55 Born on 4 Apr 1736 in New Haven, CT.56 Anna was baptized in First Congregational Society, New Haven, on 11 Apr 1736.55

Children of James and Anna (Bradley) Blakeslee, born at New Haven:
    i. Anna Blakeslee, b. 25 Aug 1756;
    ii. Nathaniel Blakeslee, b. 11 Apr 1760,
    iii. David Blakeslee, b. 7 Feb 1766; and
    iv. William Blakeslee, b. 19 Feb 1772.56